ARG54750
anti-KMT1B / SUV39H2 antibody
anti-KMT1B / SUV39H2 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse
Gene Regulation antibody
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes KMT1B / SUV39H2 |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | KMT1B / SUV39H2 |
| 抗原物种 | Human |
| 抗原 | KLH-conjugated synthetic peptide corresponding to aa. 93-122 (N-terminus) of Human SUV39H2 (NP_001180353.1). |
| 偶联标记 | Un-conjugated |
| 別名 | H3-K9-HMTase 2; KMT1B; Lysine N-methyltransferase 1B; Histone-lysine N-methyltransferase SUV39H2; EC 2.1.1.43; Su; Histone H3-K9 methyltransferase 2; var; Suppressor of variegation 3-9 homolog 2 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | HepG2 |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 缓冲液 | PBS and 0.09% (W/V) Sodium azide |
| 抗菌剂 | 0.09% (W/V) Sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q9EQQ0 Mouse Histone-lysine N-methyltransferase SUV39H2 Swiss-port # Q9H5I1 Human Histone-lysine N-methyltransferase SUV39H2 |
|---|---|
| 基因名称 | SUV39H2 |
| 全名 | suppressor of variegation 3-9 homolog 2 (Drosophila) |
| 生物功能 | Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation. [UniProt] |
| 细胞定位 | Nucleus. Chromosome, centromere. Note=Associates with centromeric constitutive heterochromatin. |
| 研究领域 | Gene Regulation antibody |
| 预测分子量 | 47 kDa |
检测图片 (2) Click the Picture to Zoom In
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ARG54750 anti-KMT1B / SUV39H2 antibody IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded Human breast carcinoma tissue stained with ARG54750 anti-KMT1B / SUV39H2 antibody.
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ARG54750 anti-KMT1B / SUV39H2 antibody WB image
Western blot: 35 µg of HepG2 cell lysate stained with ARG54750 anti-KMT1B / SUV39H2 antibody at 1:1000 dilution.
