ARG56296
anti-KLKB1 / Plasma Kallikrein antibody
anti-KLKB1 / Plasma Kallikrein antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes KLKB1 / Plasma Kallikrein |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | KLKB1 / Plasma Kallikrein |
| 抗原物种 | Human |
| 抗原 | Recombinant protein of Human KLKB1 / Plasma Kallikrein |
| 偶联标记 | Un-conjugated |
| 別名 | PPK; PKKD; Fletcher factor; EC 3.4.21.34; Kininogenin; KLK3; PKK; Plasma kallikrein; Plasma prekallikrein |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
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| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | KLKB1 |
| 全名 | kallikrein B, plasma (Fletcher factor) 1 |
| 背景介绍 | Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients. [provided by RefSeq, Jul 2008] |
| 生物功能 | The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. [UniProt] |
| 预测分子量 | 71 kDa |
检测图片 (2) Click the Picture to Zoom In
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ARG56296 anti-KLKB1 / Plasma Kallikrein antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Rat kidney stained with ARG56296 anti-KLKB1 / Plasma Kallikrein antibody at 1:200 dilution.
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ARG56296 anti-KLKB1 / Plasma Kallikrein antibody WB image
Western blot: Mouse brain lysate stained with ARG56296 anti-KLKB1 / Plasma Kallikrein antibody.
