ARG45365
anti-KLK7 antibody [5J28]
anti-KLK7 antibody [5J28] for IHC-Formalin-fixed paraffin-embedded sections and Human
概述
| 产品描述 | Mouse Monoclonal antibody [5J28] recognizes KLK7 |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 5J28 |
| 同位型 | IgG2 |
| 靶点名称 | KLK7 |
| 抗原物种 | Human |
| 抗原 | Recombinant Human KLK7. |
| 偶联标记 | Un-conjugated |
| 別名 | KLRC1; NKG2; NKG2A; CD159A |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Protein G chromatography |
| 缓冲液 | PBS |
| 浓度 | 0.2 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | KLK7 |
| 全名 | Kallikrein Related Peptidase 7 |
| 背景介绍 | This gene encodes a member of the kallikrein subfamily of serine proteases. These enzymes have diverse physiological functions and many kallikrein genes are biomarkers for cancer. The encoded protein has chymotrypsin-like activity and plays a role in the proteolysis of intercellular cohesive structures that precedes desquamation, the shedding of the outermost layer of the epidermis. The encoded protein may play a role in cancer invasion and metastasis, and increased expression of this gene is associated with unfavorable prognosis and progression of several types of cancer. Polymorphisms in this gene may play a role in the development of atopic dermatitis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, which is one of fifteen kallikrein subfamily members located in a gene cluster on chromosome 19. |
| 生物功能 | May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines. |
| 细胞定位 | Secreted. [UniProt] |
| 预测分子量 | 27 kDa |
| 翻译后修饰 | Disulfide bond, Glycoprotein, Zymogen. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG45365 anti-KLK7 antibody [5J28] IHC-P image
Immunohistochemistry: Human placental stained with ARG45365 anti-KLK7 antibody [5J28].
