ARG54623
anti-KLK4 antibody
anti-KLK4 antibody for Western blot and Human
Cancer antibody; Cell Biology and Cellular Response antibody; Signaling Transduction antibody
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes KLK4 |
|---|---|
| 反应物种 | Hu |
| 应用 | WB |
| 特异性 | This antibody recognizes the geneproduct hk4 of human KLK4 (alsoknown as KLK-L1), one of the manykallikrein serine proteases associatedwith carcinogenesis. KLK4 is upregulatedby androgens and progestinsand has been associated with prostateand breast cancers and possibly withother cancers. |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | KLK4 |
| 抗原物种 | Human |
| 抗原 | Peptide corresponding to aa242-254 of human KLK4 protein |
| 偶联标记 | Un-conjugated |
| 別名 | PSTS; Enamel matrix serine proteinase 1; Kallikrein-like protein 1; EMSP; PRSS17; ARM1; Serine protease 17; KLK-L1; Kallikrein-4; EC 3.4.21.-; Prostase; EMSP1; AI2A1; kallikrein |
应用说明
| 应用说明 | Western blot: use at 1:500 - 1:1,000 dilution. A band of approximately 39 kD is detected. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
|---|
属性
| 形式 | Liquid |
|---|---|
| 纯化 | affinity-purified antibody |
| 缓冲液 | PBS (pH 7.4) and 0.02% Sodium azide |
| 抗菌剂 | 0.02% Sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | KLK4 |
| 全名 | kallikrein-related peptidase 4 |
| 背景介绍 | Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In some tissues its expression is hormonally regulated. The expression pattern of a similar mouse protein in murine developing teeth supports a role for the protein in the degradation of enamel proteins. Several transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Dec 2014] |
| 生物功能 | Involved in enamel formation. [UniProt] |
| 研究领域 | Cancer antibody; Cell Biology and Cellular Response antibody; Signaling Transduction antibody |
| 预测分子量 | 27 kDa |
| 翻译后修饰 | N-glycosylated. The N-glycan structures are of complex diantennary or triantennary type, which may be further modified with up to 2 sialic acid residues. |
