ARG45244
anti-KLF10 antibody
anti-KLF10 antibody for ICC/IF,Western blot and Human
概述
| 产品描述 | Polyclonal antibody recognizes KLF10 |
|---|---|
| 反应物种 | Hu |
| 应用 | ICC/IF, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | KLF10 |
| 抗原物种 | Human |
| 抗原 | Recombinant protein containing to human KLF10. |
| 偶联标记 | Un-conjugated |
| 別名 | KLF10; KLF Transcription Factor 10; TIEG1; EGRA; TIEG; Transforming Growth Factor-Beta-Inducible Early Growth Response Protein 1; TGFB-Inducible Early Growth Response Protein 1; Krueppel-Like Factor 10; Kruppel Like Factor 10; EGR-Alpha; Zinc Finger Transcription Factor TIEG; TGFB Inducible Early Growth Response; Early Growth Response Alpha; Early Growth Response-Alpha; TIEG-1 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 实际分子量 | 55 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| 稳定剂 | 4% Trehalose |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | KLF10 |
| 全名 | KLF Transcription Factor 10 |
| 背景介绍 | This gene encodes a member of a family of proteins that feature C2H2-type zinc finger domains. The encoded protein is a transcriptional repressor that acts as an effector of transforming growth factor beta signaling. Activity of this protein may inhibit the growth of cancers, particularly pancreatic cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013] |
| 生物功能 | Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis. [UniProt] |
| 细胞定位 | Nucleus. [UniProt] |
| 预测分子量 | 53 kDa |
| 翻译后修饰 | Phosphoprotein ; Ubl conjugation. [UniProt] |
