ARG55850
anti-KISS1R / GRP54 antibody
anti-KISS1R / GRP54 antibody for Western blot and Human,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes KISS1R |
|---|---|
| 反应物种 | Hu, Rat |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | KISS1R / GRP54 |
| 抗原物种 | Human |
| 抗原 | KLH-conjugated synthetic peptide corresponding to aa. 235-263 (Center) of Human KISS1R. |
| 偶联标记 | Un-conjugated |
| 別名 | G-protein coupled receptor 54; Metastin receptor; Kisspeptins receptor; HOT7T175; HH8; CPPB1; AXOR12; Hypogonadotropin-1; KiSS-1 receptor; hOT7T175; KISS-1R; GPR54; G-protein coupled receptor OT7T175; KiSS-1R |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | HepG2 |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A and immunogen peptide. |
| 缓冲液 | PBS and 0.09% (W/V) Sodium azide |
| 抗菌剂 | 0.09% (W/V) Sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | KISS1R |
| 全名 | KISS1 receptor |
| 背景介绍 | The protein encoded by this gene is a galanin-like G protein-coupled receptor that binds metastin, a peptide encoded by the metastasis suppressor gene KISS1. The tissue distribution of the expressed gene suggests that it is involved in the regulation of endocrine function, and this is supported by the finding that this gene appears to play a role in the onset of puberty. Mutations in this gene have been associated with hypogonadotropic hypogonadism and central precocious puberty. [provided by RefSeq, Jul 2008] |
| 生物功能 | Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins. [UniProt] |
| 细胞定位 | Cell membrane; Multi-pass membrane protein. |
| 预测分子量 | 43 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG55850 anti-KISS1R / GRP54 antibody WB image
Western blot: 35 µg of HepG2 cell lysate stained with ARG55850 anti-KISS1R / GRP54 antibody.
