ARG53982
anti-KDM5C / Jarid 1C / SMCX antibody
anti-KDM5C / Jarid 1C / SMCX antibody for ICC/IF,Western blot and Human
Gene Regulation antibody
概述
| 产品描述 | Mouse Monoclonal antibody recognizes KDM5C / Jarid 1C / SMCX |
|---|---|
| 反应物种 | Hu |
| 应用 | ICC/IF, WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 同位型 | IgG2a |
| 靶点名称 | KDM5C / Jarid 1C / SMCX |
| 抗原物种 | Human |
| 抗原 | Purified recombinant human KDM5C / Jarid1C / SMCX protein fragments expressed in E.coli |
| 偶联标记 | Un-conjugated |
| 別名 | XE169; SMCX; DXS1272E; JARID1C; Jumonji/ARID domain-containing protein 1C; Protein Xe169; Histone demethylase JARID1C; EC 1.14.11.-; MRX13; MRXJ; Lysine-specific demethylase 5C; MRXSJ; Protein SmcX; MRXSCJ |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 实际分子量 | 220 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified |
| 缓冲液 | 0.1M Tris-Glycine (pH 7.4), 150 mM NaCl, 0.2% Sodium azide and 50% Glycerol |
| 抗菌剂 | 0.2% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | KDM5C |
| 全名 | lysine (K)-specific demethylase 5C |
| 背景介绍 | Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. |
| 生物功能 | Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity). [UniProt] |
| 细胞定位 | Nucleus |
| 研究领域 | Gene Regulation antibody |
| 预测分子量 | 176 kDa |
检测图片 (2) Click the Picture to Zoom In
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ARG53982 anti-KDM5C / Jarid 1C / SMCX antibody ICC/IF image
Immunofluorescence: HeLa cells stained with ARG53982 anti-KDM5C / Jarid 1C / SMCX antibody at 1:150 dilution.
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ARG53982 anti-KDM5C / Jarid 1C / SMCX antibody WB image
Western blot: MCF7 cell lysate stained with ARG53982 anti-KDM5C / Jarid 1C / SMCX antibody at 1:500 dilution.
