ARG41836
anti-KDM1B / LSD2 antibody
anti-KDM1B / LSD2 antibody for Flow cytometry,ICC/IF,Immunoprecipitation,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes KDM1B / LSD2 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | FACS, ICC/IF, IP, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | KDM1B / LSD2 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide of Human KDM1B / LSD2. |
| 偶联标记 | Un-conjugated |
| 別名 | dJ298J15.2; Lysine-specific histone demethylase 1B; Flavin-containing amine oxidase domain-containing protein 1; C6orf193; EC 1.-.-.-; Lysine-specific histone demethylase 2; AOF1; LSD2; bA204B7.3 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||||
| 阳性对照 | HeLa | ||||||||||
| 实际分子量 | ~ 88 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q8CIG3 Mouse Lysine-specific histone demethylase 1B Swiss-port # Q8NB78 Human Lysine-specific histone demethylase 1B |
|---|---|
| 基因名称 | KDM1B |
| 全名 | lysine (K)-specific demethylase 1B |
| 背景介绍 | Flavin-dependent histone demethylases, such as KDM1B, regulate histone lysine methylation, an epigenetic mark that regulates gene expression and chromatin function (Karytinos et al., 2009 [PubMed 19407342]).[supplied by OMIM, Oct 2009] |
| 生物功能 | Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4 (By similarity). [UniProt] |
| 细胞定位 | Nucleus. [UniProt] |
| 预测分子量 | 92 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG41836 anti-KDM1B / LSD2 antibody WB image
Western blot: HeLa cell lysate stained with ARG41836 anti-KDM1B / LSD2 antibody.
