ARG22225
anti-KCNT1 antibody [S3-26]
anti-KCNT1 antibody [S3-26] for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Mouse Monoclonal antibody [S3-26] recognizes KCNT1 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, IHC-P, WB |
| 特异性 | Detects ~140kDa. Weak human detection. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | S3-26 |
| 同位型 | IgG1 |
| 靶点名称 | KCNT1 |
| 抗原物种 | Rat |
| 抗原 | Fusion protein around aa. 1168-1237 of Rat KCNT1 |
| 偶联标记 | Un-conjugated |
| 別名 | EIEE14; SLACK; Potassium channel subfamily T member 1; Slo2.2; KCa4.1; ENFL5; bA100C15.2 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 缓冲液 | PBS (pH 7.4), 0.09% Sodium azide and 50% Glycerol |
| 抗菌剂 | 0.09% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | Kcnt1 |
| 全名 | potassium channel, sodium-activated subfamily T, member 1 |
| 背景介绍 | Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a sodium-activated potassium channel subunit which is thought to function in ion conductance and developmental signaling pathways. Mutations in this gene cause the early-onset epileptic disorders, malignant migrating partial seizures of infancy and autosomal dominant nocturnal frontal lobe epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012] |
| 生物功能 | Outwardly rectifying potassium channel subunit that may coassemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro) (By similarity). [UniProt] |
| 细胞定位 | Cell membrane |
| 预测分子量 | 138 kDa |
| 翻译后修饰 | Phosphorylated by protein kinase C. Phosphorylation of the C-terminal domain increases channel activity (By similarity). |
检测图片 (1) Click the Picture to Zoom In
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ARG22225 anti-KCNT1 antibody [S3-26] WB image
Western blot: Rat brain membrane lysate stained with ARG22225 anti-KCNT1 antibody [S3-26] at 1:1000 dilution.
