ARG40341
anti-KCNS3 / Kv9.3 antibody
anti-KCNS3 / Kv9.3 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes KCNS3 / Kv9.3 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | KCNS3 / Kv9.3 |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 1-180 of Human KCNS3 (NP_002243.3). |
| 偶联标记 | Un-conjugated |
| 別名 | KV9.3; Delayed-rectifier K; Potassium voltage-gated channel subfamily S member 3; Voltage-gated potassium channel subunit Kv9.3 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | Rat brain, Mouse brain and A549 | ||||||
| 实际分子量 | ~63 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | KCNS3 |
| 全名 | potassium voltage-gated channel, modifier subfamily S, member 3 |
| 背景介绍 | Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2 types: those that are functional by themselves and those that are electrically silent but capable of modulating the activity of specific functional alpha subunits. The protein encoded by this gene is not functional by itself but can form heteromultimers with member 1 and with member 2 (and possibly other members) of the Shab-related subfamily of potassium voltage-gated channel proteins. This gene belongs to the S subfamily of the potassium channel family. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013] |
| 生物功能 | Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. Heterotetrameric channel activity formed with KCNB1 show increased current amplitude with the threshold for action potential activation shifted towards more negative values in hypoxic-treated pulmonary artery smooth muscle cells (By similarity). [UniProt] |
| 细胞定位 | Cell membrane; Multi-pass membrane protein. Note=May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1 (PubMed:10484328). [UniProt] |
| 预测分子量 | 56 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG40341 anti-KCNS3 / Kv9.3 antibody WB image
Western blot: 25 µg of Rat brain, Mouse brain and A549 cell lysates stained with ARG40341 anti-KCNS3 / Kv9.3 antibody at 1:1000 dilution.
