ARG41426
anti-KAT7 / HBO1 / MYST2 antibody
anti-KAT7 / HBO1 / MYST2 antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes KAT7 / HBO1 / MYST2 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, IHC-P, IP, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | KAT7 / HBO1 / MYST2 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide derived from Human KAT7 / HBO1 / MYST2 Component of the HBO1 complex. |
| 偶联标记 | Un-conjugated |
| 別名 | EC 2.3.1.48; ZC2HC7; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2; HBOA; Lysine acetyltransferase 7; Histone acetyltransferase KAT7; MYST-2; HBO1; MYST2; Histone acetyltransferase binding to ORC1 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||||
| 实际分子量 | ~ 75 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | KAT7 |
| 全名 | K(lysine) acetyltransferase 7 |
| 生物功能 | Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Specifically represses AR-mediated transcription. [UniProt] |
| 细胞定位 | Nucleus, nucleoplasm. Cytoplasm, cytosol. Nucleus. Note=Associates with replication origins specifically during the G1 phase of the cell cycle (PubMed:18832067). [UniProt] |
| 预测分子量 | 71 kDa |
| 翻译后修饰 | Phosphorylation at Ser-57 by PLK1 during mitosis seems important for prereplicative complex formation and DNA replication licensing, and requires prior phosphorylation at Thr-85 and Thr-88 by CDK1 (PubMed:18250300). Autoacetylation at Lys-432 is required for proper function. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG41426 anti-KAT7 / HBO1 / MYST2 antibody WB image
Western blot: 50 µg of samples under reducing conditions. MCF7, NIH/3T3 and C6 cell lysates stained with ARG41426 anti-KAT7 / HBO1 / MYST2 antibody at 0.5 µg/ml dilution, overnight at 4°C.
