ARG67083
anti-Islet 1 antibody [SQab30356]
anti-Islet 1 antibody [SQab30356] for IHC-Formalin-fixed paraffin-embedded sections and Human
Cell Biology and Cellular Response antibody; Controls and Markers antibody; Developmental Biology antibody; Neuroscience antibody
概述
| 产品描述 | Recombinant Rabbit Monoclonal antibody [SQab30356] recognizes Islet 1 |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P |
| 宿主 | Rabbit |
| 克隆 | Monoclonal |
| 克隆号 | SQab30356 |
| 同位型 | IgG |
| 靶点名称 | Islet 1 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide of Islet 1. |
| 偶联标记 | Un-conjugated |
| 別名 | ISL1; ISL LIM Homeobox 1; ISLET1; Isl-1; Insulin Gene Enhancer Protein ISL-1; Islet-1; ISL1 Transcription Factor, LIM/Homeodomain, (Islet-1) |
应用说明
| 应用建议 |
|
||||
|---|---|---|---|---|---|
| 应用说明 | IHC-P: Antigen Retrieval: Heat mediation was performed in Tris/EDTA buffer (pH 9.0). * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A. |
| 缓冲液 | PBS, 0.01% Sodium azide, 40% Glycerol and 0.05% BSA. |
| 抗菌剂 | 0.01% Sodium azide |
| 稳定剂 | 40% Glycerol and 0.05% BSA |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P61371 Human Insulin gene enhancer protein ISL-1 |
|---|---|
| 基因名称 | ISL1 |
| 全名 | ISL LIM Homeobox 1 |
| 背景介绍 | This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young. |
| 生物功能 | DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Cooperates with the transcription factor POU4F2 to achieve maximal levels of expression of RGC target genes and RGC fate specification in the developing retina. Involved in the specification of motor neurons in cooperation with LHX3 and LDB1 (By similarity). |
| 细胞定位 | Nucleus |
| 研究领域 | Cell Biology and Cellular Response antibody; Controls and Markers antibody; Developmental Biology antibody; Neuroscience antibody |
| 预测分子量 | 39 kDa |
| 翻译后修饰 | Phosphoprotein, Ubl conjugation |
检测图片 (1) Click the Picture to Zoom In
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ARG67083 anti-Islet 1 antibody [SQab30356] IHC-P image
Immunohistochemistry: Human pancreas stained with ARG67083 anti-Islet 1 antibody [SQab30356].
