ARG44486
anti-ITGB3BP antibody
anti-ITGB3BP antibody for ICC/IF,Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes ITGB3BP |
|---|---|
| 反应物种 | Hu |
| 应用 | ICC/IF, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | ITGB3BP |
| 抗原物种 | Human |
| 抗原 | Human ITGB3BP recombinant protein |
| 偶联标记 | Un-conjugated |
| 別名 | ITGB3BP; Integrin Subunit Beta 3 Binding Protein; NRIF3; CENPR; Centromere Protein R; HSU37139; TAP20; Integrin Beta 3 Binding Protein (Beta3-Endonexin); Nuclear Receptor-Interacting Factor 3; Integrin Beta-3-Binding Protein; Beta3-Endonexin; CENP-R; Beta 3 Endonexin |
应用说明
| 应用建议 |
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| 应用说明 | The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified with Immunogen. |
| 缓冲液 | 0.9% NaCl, 0.2% Na2HPO4, 0.05% Sodium azide and 4% Trehalose. |
| 抗菌剂 | 0.05% Sodium azide |
| 稳定剂 | 4% Trehalose |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | ITGB3BP |
| 全名 | Integrin Subunit Beta 3 Binding Protein |
| 背景介绍 | This gene encodes a transcriptional coregulator that binds to and enhances the activity of members of the nuclear receptor families, thyroid hormone receptors and retinoid X receptors. This protein also acts as a corepressor of NF-kappaB-dependent signaling. This protein induces apoptosis in breast cancer cells through a caspase 2-mediated signaling pathway. This protein is also a component of the centromere-specific histone H3 variant nucleosome associated complex (CENP-NAC) and may be involved in mitotic progression by recruiting the histone H3 variant CENP-A to the centromere. Alternate splicing results in multiple transcript variants. |
| 生物功能 | Transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid. Acts as a coactivator for estrogen receptor alpha. Acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. Induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. May also act as an inhibitor of cyclin A-associated kinase. Also acts a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporati |
| 细胞定位 | Centromere, Chromosome, Cytoplasm, Kinetochore, Nucleus |
| 预测分子量 | 20 kDa |
| 翻译后修饰 | Isopeptide bond, Phosphoprotein, Ubl conjugation |
检测图片 (2) Click the Picture to Zoom In
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ARG44486 anti-ITGB3BP antibody ICC/IF image
Immunofluorescence: A549 stained with ARG44486 anti-ITGB3BP antibody at 5 μg/mL dilution.
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ARG44486 anti-ITGB3BP antibody WB image
Western blot: 293T, K562 and A431 stained with ARG44486 anti-ITGB3BP antibody at 0.5 μg/mL dilution.
