ARG44506
anti-IRS4 antibody
anti-IRS4 antibody for Flow cytometry,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes IRS4 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | FACS, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | IRS4 |
| 抗原物种 | Human |
| 抗原 | Human IRS4 recombinant protein |
| 偶联标记 | Un-conjugated |
| 別名 | IRS4; Insulin Receptor Substrate 4; IRS-4; PY160; 160 KDa Phosphotyrosine Protein; Phosphoprotein Of 160 Kda; Pp160; CHNG9; Py160 |
应用说明
| 应用建议 |
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| 应用说明 | The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified with Immunogen. |
| 缓冲液 | 0.9% NaCl, 0.2% Na2HPO4, 0.05% Sodium azide and 4% Trehalose. |
| 抗菌剂 | 0.05% Sodium azide |
| 稳定剂 | 4% Trehalose |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | IRS4 |
| 全名 | Insulin Receptor Substrate 4 |
| 背景介绍 | IRS4 encodes the insulin receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation. |
| 生物功能 | Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2. |
| 细胞定位 | Cell membrane, Membrane |
| 预测分子量 | 134 kDa |
| 翻译后修饰 | Phosphoprotein |
检测图片 (9) Click the Picture to Zoom In
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ARG44506 anti-IRS4 antibody IHC-P image
Immunohistochemistry: Human intestine stained with ARG44506 anti-IRS4 antibody at 2 μg/mL dilution.
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ARG44506 anti-IRS4 antibody WB image
Western blot: 293T stained with ARG44506 anti-IRS4 antibody at 0.5 μg/mL dilution.
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ARG44506 anti-IRS4 antibody FACS image
Flow Cytometry: HeLa stained with ARG44506 anti-IRS4 antibody at 1 μg/10^6 cells dilution.
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ARG44506 anti-IRS4 antibody IHC-P image
Immunohistochemistry: Rat testis stained with ARG44506 anti-IRS4 antibody at 2 μg/mL dilution.
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ARG44506 anti-IRS4 antibody WB image
Western blot: Rat brain and Rat testis stained with ARG44506 anti-IRS4 antibody at 0.5 μg/mL dilution.
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ARG44506 anti-IRS4 antibody IHC-P image
Immunohistochemistry: Mouse testis stained with ARG44506 anti-IRS4 antibody at 2 μg/mL dilution.
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ARG44506 anti-IRS4 antibody WB image
Western blot: Mouse brain and Mouse testis stained with ARG44506 anti-IRS4 antibody at 0.5 μg/mL dilution.
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ARG44506 anti-IRS4 antibody IHC-P image
Immunohistochemistry: Human breast cancer stained with ARG44506 anti-IRS4 antibody at 2 μg/mL dilution.
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ARG44506 anti-IRS4 antibody IHC-P image
Immunohistochemistry: Human colon adenocarcinoma stained with ARG44506 anti-IRS4 antibody at 2 μg/mL dilution.
