ARG67038
anti-INSM 1 antibody [SQab30324]
anti-INSM 1 antibody [SQab30324] for IHC-Formalin-fixed paraffin-embedded sections and Human
概述
| 产品描述 | Recombinant rabbit Monoclonal antibody [SQab30324] recognizes INSM 1 |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P |
| 宿主 | Rabbit |
| 克隆 | Monoclonal |
| 克隆号 | SQab30324 |
| 同位型 | IgG |
| 靶点名称 | INSM 1 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide of Human INSM 1. |
| 偶联标记 | Un-conjugated |
| Protein Full name | Insulinoma-associated protein 1 |
| 別名 | INSM1, INSM Transcriptional Repressor 1, IA1, IA-1, Insulinoma-Associated Protein 1, Zinc Finger Protein IA-1, Insulinoma-Associated 1, Insulinoma Associated 1 |
应用说明
| 应用建议 |
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| 应用说明 | IHC-P: Antigen Retrieval: Heat mediated was performed using Tris/EDTA buffer (pH 9.0). Incubate the samples at RT (18-25°C) for 44 min. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
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| 阳性对照 | Human small cell neuroendocrine carcinoma |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A. |
| 缓冲液 | PBS, 0.01% Sodium azide, 40% Glycerol and 0.05%BSA. |
| 抗菌剂 | 0.01% Sodium azide |
| 稳定剂 | 40% Glycerol and 0.05%BSA |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 基因名称 | INSM1 |
|---|---|
| 全名 | INSM Transcriptional Repressor 1 |
| 背景介绍 | Insulinoma-associated 1 (INSM1) gene is intronless and encodes a protein containing both a zinc finger DNA-binding domain and a putative prohormone domain. This gene is a sensitive marker for neuroendocrine differentiation of human lung tumors. [provided by RefSeq, Jul 2008] |
| 生物功能 | Sequence-specific DNA-binding transcriptional regulator that plays a key role in neurogenesis and neuroendocrine cell differentiation during embryonic and/or fetal development. Binds to the consensus sequence 5'-[TG][TC][TC][TT][GA]GGG[CG]A-3' in target promoters. Acts as a transcriptional repressor of NEUROD1 and INS expression via its interaction with cyclin CCND1 in a cell cycle-independent manner. Negatively regulates skeletal muscle-specific gene expression in endocrine cells of the pituitary by inhibiting the Notch signaling pathway. Represses target gene transcription by recruiting chromatin-modifying factors, such as HDAC1, HDAC2, HDAC3, KDM1A and RCOR1 histone deacetylases. Binds to its own promoter, suggesting autoregulation as a self-control feedback mechanism. Competes with histone H3 for the same binding site on the histone demethylase complex formed by KDM1A and RCOR1, and thereby inhibits demethylation of histone H3 at 'Lys-4'. [Uniprot] |
| 细胞定位 | Nucleus |
| 预测分子量 | 53 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG67038 anti-INSM-1 antibody [SQab30324] IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded small cell neuroendocrine carcinoma stained with ARG67047 anti-Survivin antibody [SQab30320].
