ARG57131
anti-ING2 / ING1L antibody [39E5]
anti-ING2 / ING1L antibody [39E5] for Western blot and Human
概述
| 产品描述 | Mouse Monoclonal antibody [39E5] recognizes ING2 / ING1L |
|---|---|
| 反应物种 | Hu |
| 应用 | WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 39E5 |
| 同位型 | IgG1b, kappa |
| 靶点名称 | ING2 / ING1L |
| 抗原物种 | Human |
| 抗原 | Recombinant fragment around aa. 1-280 of Human ING2 |
| 偶联标记 | Un-conjugated |
| 別名 | ING1L; ING1Lp; Inhibitor of growth protein 2; Inhibitor of growth 1-like protein; p33ING2; p32 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A. |
| 缓冲液 | PBS (pH 7.4), 0.02% Sodium azide and 10% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 10% Glycerol |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | ING2 |
| 全名 | inhibitor of growth family, member 2 |
| 背景介绍 | This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] |
| 生物功能 | Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs). [UniProt] |
| 预测分子量 | 33 kDa |
| 翻译后修饰 | Sumoylation enhances its association with SIN3A and is required for binding to some target gene promoters, this is the case for TMEM71. |
检测图片 (1) Click the Picture to Zoom In
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ARG57131 anti-ING2 / ING1L antibody [39E5] WB image
Western blot: 40 µg of HeLa cell lysate stained with ARG57131 anti-ING2 / ING1L antibody [39E5] at 1:1000.
