ARG40388
anti-IMPDH2 antibody
anti-IMPDH2 antibody for ICC/IF,Western blot and Human,Mouse
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes IMPDH2 |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | ICC/IF, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | IMPDH2 |
| 抗原物种 | Human |
| 抗原 | Recombinant full length protein of Human IMPDH2. |
| 偶联标记 | Un-conjugated |
| 別名 | IMPD2; EC 1.1.1.205; IMPDH-II; IMP dehydrogenase 2; IMPD 2; Inosine-5'-monophosphate dehydrogenase 2; IMPDH 2 |
应用说明
| 应用建议 |
|
||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 实际分子量 | 56 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | 0.42% Potassium phosphate (pH 7.3), 0.87% NaCl, 0.01% Sodium azide and 30% Glycerol. |
| 抗菌剂 | 0.01% Sodium azide |
| 稳定剂 | 30% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P12268 Human Inosine-5'-monophosphate dehydrogenase 2 Swiss-port # P24547 Mouse Inosine-5'-monophosphate dehydrogenase 2 |
|---|---|
| 基因名称 | IMPDH2 |
| 全名 | IMP (inosine 5'-monophosphate) dehydrogenase 2 |
| 背景介绍 | This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008] |
| 生物功能 | Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. [UniProt] |
| 细胞定位 | Cytoplasm. Nucleus. [UniProt] |
| 预测分子量 | 56 kDa |
| 翻译后修饰 | The N-terminus is blocked. [UniProt] |
检测图片 (2) Click the Picture to Zoom In
-
ARG40388 anti-IMPDH2 antibody ICC/IF image
Immunofluorescence: Formalin-fixed HeLa cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were stained with ARG40388 anti-IMPDH2 antibody (red) in 3% BSA-PBS and incubated overnight at 4°C.
-
ARG40388 anti-IMPDH2 antibody WB image
Western blot: HeLa, PC3, Mouse spleen and Mouse heart lysates stained with ARG40388 anti-IMPDH2 antibody.
