ARG40346
anti-IMPDH1 antibody
anti-IMPDH1 antibody for ICC/IF,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes IMPDH1 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | IMPDH1 |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 434-563 of Human IMPDH1 (NP_899066.1). |
| 偶联标记 | Un-conjugated |
| 別名 | IMPD1; EC 1.1.1.205; IMP dehydrogenase 1; IMPDH-I; IMPDH 1; LCA11; IMPD 1; IMPD; sWSS2608; Inosine-5'-monophosphate dehydrogenase 1; RP10 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | Mouse lung and HL-60 | ||||||
| 实际分子量 | 57 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P20839 Human Inosine-5'-monophosphate dehydrogenase 1 Swiss-port # P50096 Mouse Inosine-5'-monophosphate dehydrogenase 1 |
|---|---|
| 基因名称 | IMPDH1 |
| 全名 | IMP (inosine 5'-monophosphate) dehydrogenase 1 |
| 背景介绍 | The protein encoded by this gene acts as a homotetramer to regulate cell growth. The encoded protein is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5'-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008] |
| 生物功能 | Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. [UniProt] |
| 细胞定位 | Cytoplasm. Nucleus. [UniProt] |
| 预测分子量 | 55 kDa |
检测图片 (2) Click the Picture to Zoom In
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ARG40346 anti-IMPDH1 antibody WB image
Western blot: 25 µg of HL-60 cell lysate stained with ARG40346 anti-IMPDH1 antibody at 1:1000 dilution.
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ARG40346 anti-IMPDH1 antibody WB image
Western blot: 25 µg of Mouse lung lysate stained with ARG40346 anti-IMPDH1 antibody at 1:1000 dilution.
