ARG59394
anti-IL36 alpha antibody
anti-IL36 alpha antibody for Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes IL36 alpha |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | IL36 alpha |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 1-158 of Human IL36 alpha (NP_055255.1). |
| 偶联标记 | Un-conjugated |
| 別名 | FIL1; Interleukin-36 alpha; IL-1F6; IL-1 epsilon; Interleukin-1 family member 6; FIL1E; FIL1(EPSILON); FIL1 epsilon; IL1(EPSILON); IL1F6; Interleukin-1 epsilon |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | BT-474 | ||||
| 实际分子量 | 18 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | IL36A |
| 全名 | interleukin 36, alpha |
| 生物功能 | Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6. In cultured monocytes upregulates expression of IL-1A, IL-1B and IL-6. In myeloid dendritic cells involved in cell maturation by upregulating surface expression of CD83, CD86 and HLA-DR. In monocyte-derived dendritic cells facilitates dendritic cell maturation and drives T cell proliferation. May play a role in proinflammatory effects in the lung. [UniProt] |
| 细胞定位 | Secreted. [UniProt] |
| 预测分子量 | 18 kDa |
| 翻译后修饰 | N-terminal truncation leads to a dramatic enhancement of its activity (>1000-fold). [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG59394 anti-IL36 alpha antibody WB image
Western blot: 25 µg of BT-474 cell lysate stained with ARG59394 anti-IL36 alpha antibody at 1:1000 dilution.
