ARG46204
anti-IL22RA1 antibody
anti-IL22RA1 antibody for Western blot,IHC-Formalin-fixed paraffin-embedded sections,ICC/IF and Human,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes IL22RA1 |
|---|---|
| 反应物种 | Hu, Rat |
| 应用 | ICC/IF, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | IL22RA1 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide near the amino terminus of humanIL22RA1. |
| 偶联标记 | Un-conjugated |
| 別名 | IL22RA1; interleukin 22 receptor, alpha 1; IL-22 Receptor; IL22R; CRF2-9; IL22R1; IL22R; Interleukin-22 receptor subunit alpha-1; Cytokine receptor class-II member 9; IL-22 receptor subunit alpha-1 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 实际分子量 | 65 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity chromatography purified |
| 缓冲液 | PBS and 0.02% Sodium azide. |
| 抗菌剂 | 0.02% Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -254°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q8N6P7 Human Interleukin-22 receptor subunit alpha-1 |
|---|---|
| 基因名称 | IL22RA1 |
| 全名 | interleukin 22 receptor, alpha 1 |
| 背景介绍 | The protein encoded by this gene belongs to the class II cytokine receptor family, and has been shown to be a receptor for interleukin 22 (IL22). IL22 receptor is a protein complex that consists of this protein and interleukin 10 receptor, beta (IL10BR/CRFB4), a subunit also shared by the receptor complex for interleukin 10 (IL10). This gene and interleukin 28 receptor, alpha (IL28RA) form a cytokine receptor gene cluster in the chromosomal region 1p36. [provided by RefSeq, Jul 2008] |
| 生物功能 | Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation. [UniProt] |
| 细胞定位 | Cell membrane. [UniProt] |
| 预测分子量 | 63 kDa |
| 翻译后修饰 | Phosphoprotein; Ubl conjugation; Disulfide bond; Glycoprotein. [UniProt] |
