ARG59299
anti-IL17C antibody
anti-IL17C antibody for Western blot and Mouse
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes IL17C |
|---|---|
| 反应物种 | Ms |
| 预测物种 | Rat |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | IL17C |
| 抗原物种 | Mouse |
| 抗原 | Recombinant protein corresponding to H15-Q194 of Mouse IL17C. |
| 偶联标记 | Un-conjugated |
| 別名 | IL-17C; CX2; Interleukin-17C; Cytokine CX2 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | 0.9% NaCl, 0.2% Na2HPO4, 0.05% Sodium azide and 4% Trehalose. |
| 抗菌剂 | 0.05% Sodium azide |
| 稳定剂 | 4% Trehalose |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | IL17C |
| 全名 | interleukin 17C |
| 背景介绍 | The protein encoded by this gene is a T cell-derived cytokine that shares the sequence similarity with IL17. This cytokine was reported to stimulate the release of tumor necrosis factor alpha and interleukin 1 beta from a monocytic cell line. The expression of this cytokine was found to be restricted to activated T cells. [provided by RefSeq, Jul 2008] |
| 生物功能 | Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases. [UniProt] |
| 细胞定位 | Secreted. [UniProt] |
| 预测分子量 | 22 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG59299 anti-IL17C antibody WB image
Western blot: 1 ng of Recombinant Mouse IL17C protein stained with ARG59299 anti-IL17C antibody at 0.5 µg/ml, overnight at 4°C.
