ARG43845
anti-IL17 / IL17A antibody [9F9]
anti-IL17 / IL17A antibody [9F9] for ELISA,Flow cytometry,Immunoprecipitation and Human
概述
| 产品描述 | Mouse Monoclonal antibody recognizes IL17 / IL17A. |
|---|---|
| 反应物种 | Hu |
| 应用 | ELISA, FACS, IP |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 9F9 |
| 同位型 | IgG1 kappa |
| 靶点名称 | IL17 / IL17A |
| 抗原物种 | Human |
| 抗原 | Human IL17 / IL17A fusion protein. |
| 偶联标记 | Un-conjugated |
| Protein Full name | Interleukin-17A |
| 別名 | L17A; Interleukin 17A; IL-17A; IL-17; CTLA8; IL17; Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8); Cytotoxic T-Lymphocyte-Associated Protein 8; Cytotoxic T-Lymphocyte-Associated Antigen 8; Interleukin-17A; CTLA-8; Interleukin-17; ILA17 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Protein-A affinity chromatography |
| 缓冲液 | PBS (pH 7.4) and 15 mM Sodium azide |
| 抗菌剂 | 15 mM Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | Aliquot and store in the dark at 4°C. Keep protected from prolonged exposure to light. Do not freeze. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | IL17A |
| 全名 | Interleukin 17A |
| 背景介绍 | This gene is a member of the IL-17 receptor family which includes five members (IL-17RA-E) and the encoded protein is a proinflammatory cytokine produced by activated T cells. IL-17A-mediated downstream pathways induce the production of inflammatory molecules, chemokines, antimicrobial peptides, and remodeling proteins. The encoded protein elicits crucial impacts on host defense, cell trafficking, immune modulation, and tissue repair, with a key role in the induction of innate immune defenses. This cytokine stimulates non-hematopoietic cells and promotes chemokine production thereby attracting myeloid cells to inflammatory sites. This cytokine also regulates the activities of NF-kappaB and mitogen-activated protein kinases and can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). IL-17A plays a pivotal role in various infectious diseases, inflammatory and autoimmune disorders, and cancer. High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The lung damage induced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL17A. [provided by RefSeq, Sep 2020] |
| 生物功能 | Signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation. |
| 细胞定位 | Secreted |
| 预测分子量 | 18 kDa |
| 翻译后修饰 | Disulfide bond; Glycoprotein |
检测图片 (1) Click the Picture to Zoom In
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ARG43845 anti-IL17 / IL17A antibody [9F9] FACS image
Flow Cytometry: Human PHA stained with ARG43845 anti-IL17 / IL17A antibody [9F9] at 0.5 μg/ml.
