ARG10203
anti-IL16 antibody [323] (HRP)
anti-IL16 antibody [323] (HRP) for ELISA and Human
Cell Biology and Cellular Response antibody; Gene Regulation antibody
概述
| 产品描述 | HRP-conjugated Mouse Monoclonal antibody [323] recognizes Human IL-16 |
|---|---|
| 反应物种 | Hu |
| 应用 | ELISA |
| 特异性 | mAb 323 exhibits no detectable cross-reaction with human serum albumin, bovine serum albumin and other human cytokines or growth factors tested, such as IL-1β, IL-8, IL-7 MCAF, TGF-β1, EGF, bFGF, GM-CSF, M-CSF, TNF-α. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 323 |
| 同位型 | IgG2a, kappa |
| 靶点名称 | IL16 |
| 抗原物种 | Human |
| 抗原 | Purified recombinant human IL-16 |
| 偶联标记 | HRP |
| 別名 | prIL-16; Lymphocyte chemoattractant factor; PRIL16; IL-16; NIL16; LCF; Pro-interleukin-16 |
应用说明
| 应用说明 | ELISA: In combination with capture antibody clone 398 (Cat. No.: ARG10202), this HRP conjugated antibody can be used as a tracer antibody for human IL-16 detection. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
|---|
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Protein G affinity purified |
| 缓冲液 | 0.01M PBS (pH 7.2) and 50% Glycerol |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Keep the antibody in the dark and keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | IL16 |
| 全名 | interleukin 16 |
| 背景介绍 | Interleukin 16 (IL-16) is a pleiotropic cytokine, possessing immunomodulation function to allergic inflammatory diseases such as Crohn's disease and ulcerative colitis. IL-16 utilizes CD4 as its primary receptor. IL-16 is a chemo-attractant to CD4+ T helper 1 cells. To CD4+ T helper 2 cells, IL-16 has an inhibitory effect on the antigen-mediated CD3/T cell receptor activation. IL-16 has been shown to suppress HIV infection in lymphocytes and monocytes. |
| 生物功能 | Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane. Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells. [UniProt] |
| 产品亮点 | Related Antibody Duos and Panels: ARG30075 IL16 ELISA Antibody Duo Related products: IL16 antibodies; IL16 ELISA Kits; IL16 Duos / Panels; Anti-Mouse IgG secondary antibodies; |
| 研究领域 | Cell Biology and Cellular Response antibody; Gene Regulation antibody |
| 预测分子量 | 142 kDa |
| 翻译后修饰 | Isoform 3 is synthesized as a chemo-attractant inactive precursor in hemopoietic tissues and is proteolytically cleaved by caspase-3 to yield IL-16. |
