概述

产品描述	Rabbit Polyclonal antibody recognizes IL12RB1
反应物种	Hu, Ms, Rat
应用	WB
宿主	Rabbit
克隆	Polyclonal
同位型	IgG
靶点名称	IL12RB1
抗原物种	Human
抗原	Recombinant protein of Human IL12RB1
偶联标记	Un-conjugated
別名	Interleukin-12 receptor subunit beta-1; IL-12R-beta-1; IL12RB; IL-12R-BETA1; IL-12 receptor beta component; IL-12RB1; IL-12 receptor subunit beta-1; IMD30; CD212; IL-12R subunit beta-1; CD antigen CD212

应用说明

应用建议	应用 推荐稀释比 WB 1:500 - 1:2000
应用说明	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照	Mouse liver

属性

形式	Liquid
纯化	Affinity purification with immunogen.
缓冲液	PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol
抗菌剂	0.02% Sodium azide
稳定剂	50% Glycerol
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 16161 Mouse IL12RB1 GeneID: 3594 Human IL12RB1 Swiss-port # P42701 Human Interleukin-12 receptor subunit beta-1 Swiss-port # Q60837 Mouse Interleukin-12 receptor subunit beta-1
基因名称	IL12RB1
全名	interleukin 12 receptor, beta 1
背景介绍	The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
生物功能	Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade. [UniProt]
研究领域	Immune System antibody
预测分子量	73 kDa

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