ARG40412
anti-IL11 antibody
anti-IL11 antibody for Western blot and Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes IL11 |
|---|---|
| 反应物种 | Rat |
| 预测物种 | Ms |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | IL11 |
| 抗原物种 | Rat |
| 抗原 | Recombinant protein corresponding to P25-L199 of Rat IL11. |
| 偶联标记 | Un-conjugated |
| 別名 | Oprelvekin; Interleukin-11; AGIF; Adipogenesis inhibitory factor; IL-11 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 实际分子量 | 21 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | 0.2% Na2HPO4, 0.9% NaCl, 0.05% Sodium azide and 5% BSA. |
| 抗菌剂 | 0.05% Sodium azide |
| 稳定剂 | 5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 基因名称 | IL11 |
|---|---|
| 全名 | interleukin 11 |
| 背景介绍 | The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2012] |
| 生物功能 | Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation. Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. [UniProt] |
| 细胞定位 | Secreted. [UniProt] |
| 预测分子量 | 21 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG40412 anti-IL11 antibody WB image
Western blot: 50 ug of samples under reducing conditions. Rat liver and Rat kidney lysates stained with ARG40412 anti-IL11 antibody at 0.5 µg/ml, overnight at 4°C.
