ARG45363
anti-IL-1 R2 antibody [7D7]
anti-IL-1 R2 antibody [7D7] for IHC-Formalin-fixed paraffin-embedded sections and Mouse
概述
| 产品描述 | Rat Monoclonal antibody [7D7] recognizes IL-1 R2 |
|---|---|
| 反应物种 | Ms |
| 应用 | IHC-P |
| 宿主 | Rat |
| 克隆 | Monoclonal |
| 克隆号 | 7D7 |
| 同位型 | IgG2 |
| 靶点名称 | IL-1 R2 |
| 抗原物种 | Mouse |
| 抗原 | Recombinant protein corresponding to extracellular domain of mouse IL-1 R2. |
| 偶联标记 | Un-conjugated |
| 別名 | IL1R2; Interleukin 1 Receptor Type 2; CD121b; IL1RB; CD121 Antigen-Like Family Member B; Interleukin-1 Receptor Type II; Interleukin-1 Receptor Type 2; Interleukin-1 Receptor Beta; IL-1 Type II Receptor; IL-1R-Beta; IL-1RT-2; CDw121b; IL-1R-2; IL-1RT2; Type II Interleukin-1 Receptor, Beta; Interleukin 1 Receptor, Type II; Antigen CDw121b; CD121b Antigen; IL1R2c |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Protein G/A chromatography |
| 缓冲液 | PBS |
| 浓度 | 0.2 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | IL1R2 |
| 全名 | Interleukin 1 Receptor Type 2 |
| 背景介绍 | The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage. [provided by RefSeq, May 2012] |
| 生物功能 | Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competitive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors |
| 细胞定位 | Cell membrane; Membrane; Secreted. [UniProt] |
| 预测分子量 | 46 kDa |
| 翻译后修饰 | Disulfide bond; Glycoprotein. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG45363 anti-IL-1 R2 antibody [7D7] IHC-P image
Immunohistochemistry: Mouse Spleen stained with ARG45363 anti-IL-1 R2 antibody [7D7].
