ARG57835
anti-IGF2BP3 antibody
anti-IGF2BP3 antibody for Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes IGF2BP3 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | IGF2BP3 |
| 抗原物种 | Human |
| 抗原 | Recombinant protein of Human IGF2BP3. |
| 偶联标记 | Un-conjugated |
| 別名 | IMP3; VICKZ3; hKOC; IMP-3; KOC; KH domain-containing protein overexpressed in cancer; VICKZ family member 3; KOC1; CT98; IGF2 mRNA-binding protein 3; IGF-II mRNA-binding protein 3; Insulin-like growth factor 2 mRNA-binding protein 3 |
应用说明
| 应用建议 |
|
||||
|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | NIH/3T3 |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # O00425 Human Insulin-like growth factor 2 mRNA-binding protein 3 Swiss-port # Q9CPN8 Mouse Insulin-like growth factor 2 mRNA-binding protein 3 |
|---|---|
| 基因名称 | IGF2BP3 |
| 全名 | insulin-like growth factor 2 mRNA binding protein 3 |
| 背景介绍 | The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes. [provided by RefSeq, Jul 2008] |
| 生物功能 | RNA-binding factor that may recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. [UniProt] |
| 细胞定位 | Cytoplasm, Nucleus. [UniProt] |
| 预测分子量 | 64 kDa |
检测图片 (1) Click the Picture to Zoom In
-
ARG57835 anti-IGF2BP3 antibody WB image
Western blot: 25 µg of NIH/3T3 cell lysate stained with ARG57835 anti-IGF2BP3 antibody at 1:1000 dilution.
