ARG54644
anti-IGF1 antibody [0.T.61]
anti-IGF1 antibody [0.T.61] for IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Neutralizing,Western blot and Mouse,Rat
Cancer antibody; Developmental Biology antibody; Signaling Transduction antibody
概述
| 产品描述 | Mouse Monoclonal antibody [0.T.61] recognizes IGF1 |
|---|---|
| 反应物种 | Ms, Rat |
| 预测物种 | Chk |
| 应用 | IHC-P, IP, Neut, WB |
| 特异性 | Recognizes human Insulin-Like Growth Factor I (IGF1), Mr ~17kD (migrates to ~7kD). Crossreactivity with IGF-II is ~40%. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 0.T.61 |
| 同位型 | IgG1, kappa |
| 靶点名称 | IGF1 |
| 抗原物种 | Human |
| 抗原 | Human insulin-like growth factor I (IGF1) purified from human plasma. |
| 偶联标记 | Un-conjugated |
| 別名 | MGF; Insulin-like growth factor I; Mechano growth factor; Somatomedin-C; IGFI; IGF-I |
应用说明
| 应用建议 |
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| 应用说明 | Neut: 10-20 µg/ml can inhibit the activity of 10 ng/ml of IGF1 as determined by testing with chicken embryo fibroblasts (CEF) using an ATP endpoint assay. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
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| 阳性对照 | IHC-P: formalin-fixed, paraffin-embedded skin sections. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with Protein G. |
| 缓冲液 | 0.1M Tris-glycine (pH 7.4), 0.15 mM sodium chloride and 0.1mM EDTA |
| 稳定剂 | 0.1mM EDTA |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | IGF1 |
| 全名 | insulin-like growth factor 1 (somatomedin C) |
| 背景介绍 | The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009] |
| 生物功能 | The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. [UniProt] |
| 研究领域 | Cancer antibody; Developmental Biology antibody; Signaling Transduction antibody |
| 预测分子量 | 22 kDa |
