ARG40361
anti-IFNGR2 / IFN gamma R2 antibody
anti-IFNGR2 / IFN gamma R2 antibody for Flow cytometry,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes IFNGR2 / IFN gamma R2 |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | IFNGR2 / IFN gamma R2 |
| 抗原物种 | Human |
| 抗原 | KLH-conjugated synthetic peptide corresponding to aa. 308-337 of Human IFNGR2. |
| 偶联标记 | Un-conjugated |
| 別名 | IFNGT1; Interferon gamma receptor accessory factor 1; IFGR2; Interferon gamma receptor 2; AF-1; Interferon gamma transducer 1; IFN-gamma receptor 2; IMD28; IFN-gamma-R2 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 阳性对照 | Human skeletal muscle |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A and immunogen peptide. |
| 缓冲液 | PBS and 0.09% (W/V) Sodium azide. |
| 抗菌剂 | 0.09% (W/V) Sodium azide. |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | IFNGR2 |
| 全名 | interferon gamma receptor 2 (interferon gamma transducer 1) |
| 背景介绍 | This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. [provided by RefSeq, Jul 2008] |
| 生物功能 | Part of the receptor for interferon gamma. Required for signal transduction. This accessory factor is an integral part of the IFN-gamma signal transduction pathway and is likely to interact with GAF, JAK1, and/or JAK2. [UniProt] |
| 细胞定位 | Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Cytoplasm. Note=Has low cell surface expression and high cytoplasmic expression in T cells. The bias towards cytoplasmic expression may be due to ligand-independent receptor internalization and recycling. [UniProt] |
| 预测分子量 | 38 kDa |
检测图片 (3) Click the Picture to Zoom In
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ARG40361 anti-IFNGR2 / IFN gamma R2 antibody IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded Human lung carcinoma stained with ARG40361 anti-IFNGR2 / IFN gamma R2 antibody.
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ARG40361 anti-IFNGR2 / IFN gamma R2 antibody WB image
Western blot: 35 µg of Human skeletal muscle lysate stained with ARG40361 anti-IFNGR2 / IFN gamma R2 antibody at 1:1000 dilution.
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ARG40361 anti-IFNGR2 / IFN gamma R2 antibody FACS image
Flow Cytometry: NCI-H292 cells stained with ARG40361 anti-IFNGR2 / IFN gamma R2 antibody (bottom histogram) or without primary antibody as control (top histogram), followed by incubation with FITC labelled secondary antibody.
