ARG56283
anti-IFIT3 antibody
anti-IFIT3 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes IFIT3 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | IFIT3 |
| 抗原物种 | Human |
| 抗原 | Recombinant protein of Human IFIT3 |
| 偶联标记 | Un-conjugated |
| 別名 | GARG-49; P60; IRG2; CIG-49; IFIT-3; IFIT-4; Retinoic acid-induced gene G protein; RIG-G; Interferon-induced 60 kDa protein; ISG-60; IFI60; Interferon-induced protein with tetratricopeptide repeats 4; ISG60; IFI-60K; cig41; Interferon-induced protein with tetratricopeptide repeats 3; IFIT4; CIG49 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | A549 |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # O14879 Human Interferon-induced protein with tetratricopeptide repeats 3 Swiss-port # Q64345 Mouse Interferon-induced protein with tetratricopeptide repeats 3 |
|---|---|
| 基因名称 | IFIT3 |
| 全名 | interferon-induced protein with tetratricopeptide repeats 3 |
| 生物功能 | IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2. [UniProt] |
| 预测分子量 | 56 kDa |
检测图片 (2) Click the Picture to Zoom In
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ARG56283 anti-IFIT3 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human liver stained with ARG56283 anti-IFIT3 antibody at 1:100 dilution.
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ARG56283 anti-IFIT3 antibody WB image
Western blot: A549 cell lysate stained with ARG56283 anti-IFIT3 antibody.
