ARG42170
anti-IFI27 antibody
anti-IFI27 antibody for Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes IFI27 |
|---|---|
| 反应物种 | Hu |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | IFI27 |
| 抗原物种 | Human |
| 抗原 | KLH-conjugated synthetic peptide between aa. 72-106 of Human IFI27. |
| 偶联标记 | Un-conjugated |
| 別名 | a; Interferon alpha-inducible protein 27, mitochondrial; ISG12A; Interferon-stimulated gene 12a protein; p27; P27; ISG12; FAM14D; Interferon alpha-induced 11.5 kDa protein |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | Human spleen | ||||
| 实际分子量 | ~ 13 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A and immunogen peptide. |
| 缓冲液 | PBS and 0.09% (W/V) Sodium azide. |
| 抗菌剂 | 0.09% (W/V) Sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P40305 Human Interferon alpha-inducible protein 27, mitochondrial |
|---|---|
| 基因名称 | IFI27 |
| 全名 | interferon, alpha-inducible protein 27 |
| 生物功能 | Probable adapter protein involved in different biological processes (PubMed:22427340, PubMed:27194766). Part of the signaling pathways that lead to apoptosis (PubMed:18330707, PubMed:27673746, PubMed:24970806). Involved in type-I interferon-induced apoptosis characterized by a rapid and robust release of cytochrome C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9 (PubMed:18330707, PubMed:27673746). Also functions in TNFSF10-induced apoptosis (PubMed:24970806). May also have a function in the nucleus, where it may be involved in the interferon-induced negative regulation of the transcriptional activity of NR4A1, NR4A2 and NR4A3 through the enhancement of XPO1-mediated nuclear export of these nuclear receptors (PubMed:22427340). May thereby play a role in the vascular response to injury (By similarity). In the innate immune response, has an antiviral activity towards hepatitis C virus/HCV (PubMed:27194766, PubMed:27777077). May prevent the replication of the virus by recruiting both the hepatitis C virus non-structural protein 5A/NS5A and the ubiquitination machinery via SKP2, promoting the ubiquitin-mediated proteasomal degradation of NS5A (PubMed:27194766, PubMed:27777077). [UniProt] |
| 细胞定位 | Mitochondrion. Membrane; Multi-pass membrane protein. [UniProt] |
| 预测分子量 | 12 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG42170 anti-IFI27 antibody WB image
Western blot: 20 µg of Human spleen lysate stained with ARG42170 anti-IFI27 antibody at 1:500 dilution.
