ARG46201
anti-IEX1 / IER3 antibody
anti-IEX1 / IER3 antibody for Western blot,IHC-Formalin-fixed paraffin-embedded sections and Human,Mouse
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes IEX1 / IER3 |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | IEX1 / IER3 |
| 抗原物种 | Human |
| 抗原 | A 24 amino acid synthetic peptide within aa. 40 - 90 of human IEX1 / IER3. |
| 偶联标记 | Un-conjugated |
| 別名 | IER3; immediate early response 3; IEX-1; DIF2; IEX1; PRG1; DIF-2; GLY96; IEX-1; IEX-1L; DIF2; Radiation-inducible immediate-early gene IEX-1; Differentiation-dependent gene 2 protein; Protein DIF-2 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 实际分子量 | 17 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity chromatography purified |
| 缓冲液 | PBS and 0.02% Sodium azide. |
| 抗菌剂 | 0.02% Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -251°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P46695 Human Radiation-inducible immediate-early gene IEX-1 |
|---|---|
| 基因名称 | IER3 |
| 全名 | immediate early response 3 |
| 背景介绍 | This gene functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced apoptosis. Partially degraded and unspliced transcripts are found after virus infection in vitro, but these transcripts are not found in vivo and do not generate a valid protein. [provided by RefSeq, Jul 2008] |
| 生物功能 | May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A-PPP2R5C holoenzyme. Also acts as an ERK downstream effector mediating survival. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. [UniProt] |
| 细胞定位 | Membrane. [UniProt] |
| 预测分子量 | 17 kDa |
| 翻译后修饰 | Phosphoprotein; Glycoprotein. [UniProt] |
