ARG59296

anti-IDO1 / INDO antibody

anti-IDO1 / INDO antibody for ICC/IF,Western blot and Human

publication_link 参考文献1

概述

产品描述 Rabbit Polyclonal antibody recognizes IDO1 / INDO protein
反应物种 Hu
应用 ICC/IF, WB
宿主 Rabbit
克隆 Polyclonal
同位型 IgG
靶点名称 IDO1 / INDO
抗原物种 Human
抗原 Synthetic peptide derived from Human IDO1 / INDO.
偶联标记 Un-conjugated
別名 IDO-1; Indoleamine 2,3-dioxygenase 1; IDO; Indoleamine-pyrrole 2,3-dioxygenase; INDO; EC 1.13.11.52

应用说明

应用建议
应用 推荐稀释比
ICC/IF1:50 - 1:200
WB1:500 - 1:2000
应用说明 * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
实际分子量 ~ 40 kDa

属性

形式 Liquid
纯化 Affinity purified.
缓冲液 PBS (pH 7.4), 0.02% Sodium azide and 50% Glycerol.
抗菌剂 0.02% Sodium azide
稳定剂 50% Glycerol
存放说明 For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项 For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接

GeneID: 3620 Human IDO1

Swiss-port # P14902 Human Indoleamine 2,3-dioxygenase 1

基因名称 IDO1
全名 indoleamine 2,3-dioxygenase 1
背景介绍 This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011]
生物功能 Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen. [UniProt]
细胞定位 Cytoplasm, cytosol. [UniProt]
预测分子量 45 kDa

检测图片 (2) Click the Picture to Zoom In

  • ARG59296 anti-IDO1 / INDO antibody WB image

    Western blot: Human BM-MSCs stained with ARG59296 anti-IDO1 / INDO antibody.

    From Tai TS et al. Br J Cancer. (2025), doi: 10.1038/s41416-024-02893-3, Fig. 3. C.

  • ARG59296 anti-IDO1 / INDO antibody WB image

    Western blot: HeLa cell lysate treated with IFN gamma and stained with ARG59296 anti-IDO1 / INDO antibody.

文献引用

IL-10RA governor the expression of IDO in the instruction of lymphocyte immunity

WB / Human

Tzong-Shyuan Tai et al.
Br J Cancer.,  (2024)

publication_link

 

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