概述

产品描述	Rabbit Polyclonal antibody recognizes ID1
反应物种	Hu, Ms, Rat
应用	ICC/IF
宿主	Rabbit
克隆	Polyclonal
同位型	IgG
靶点名称	ID1
抗原物种	Human
抗原	Synthetic peptide derived from Human ID1.
偶联标记	Un-conjugated
別名	DNA-binding protein inhibitor ID-1; Class B basic helix-loop-helix protein 24; Inhibitor of DNA binding 1; ID; bHLHb24; Inhibitor of differentiation 1

应用说明

应用建议	应用 推荐稀释比 ICC/IF 1:50 - 1:200
应用说明	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

属性

形式	Liquid
纯化	Affinity purified.
缓冲液	PBS (pH 7.4), 0.02% Sodium azide and 50% Glycerol.
抗菌剂	0.02% Sodium azide
稳定剂	50% Glycerol
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 25261 Rat ID1 GeneID: 3397 Human ID1 Swiss-port # P41134 Human DNA-binding protein inhibitor ID-1 Swiss-port # P41135 Rat DNA-binding protein inhibitor ID-1
基因名称	ID1
全名	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
背景介绍	The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
生物功能	Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). [UniProt]
细胞定位	Cytoplasm. Nucleus. [UniProt]
预测分子量	16 kDa

检测图片 (1) Click the Picture to Zoom In