ARG44651
anti-ICAD antibody
anti-ICAD antibody for IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human
概述
| 产品描述 | Mouse Monoclonal antibody recognizes ICAD |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P, IP, WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 同位型 | IgG1 |
| 靶点名称 | ICAD |
| 抗原物种 | Human |
| 偶联标记 | Un-conjugated |
| 別名 | DFFA; DNA Fragmentation Factor Subunit Alpha; DFF-45; DFF45; ICAD; DFF1; DNA Fragmentation Factor, 45kDa, Alpha Polypeptide; DNA Fragmentation Factor 45 KDa Subunit; Inhibitor Of CAD; DNA Fragmentation Factor, 45 KD, Alpha Polypeptide; DNA Fragmentation Factor, 45 KD, Alpha Subunit |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Protein A purification |
| 缓冲液 | PBS with 0.09% sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # O00273 Human DNA fragmentation factor subunit alpha |
|---|---|
| 基因名称 | DFFA |
| 全名 | DNA Fragmentation Factor Subunit Alpha |
| 背景介绍 | Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| 生物功能 | Inhibitor of the caspase-activated DNase (DFF40). [UniProt] |
| 细胞定位 | Cytoplasm. [UniProt] |
| 翻译后修饰 | Acetylation, Phosphoprotein. [UniProt] |
检测图片 (3) Click the Picture to Zoom In
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ARG44651 anti-ICAD antibody IHC-P image
Immunohistochemistry: Human Testis stained with ARG44651 anti-ICAD antibody at 5 µg/mL dilution.
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ARG44651 anti-ICAD antibody WB image
Western blot: Jurkat, HepG2 and HeLa stained with ARG44651 anti-ICAD antibody at 1 µg/mL dilution.
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ARG44651 anti-ICAD antibody IP image
Immunoprecipitation: Jurkat lysate immunoprecipitated with 2.5 µg of ARG44651 anti-ICAD antibody.
