ARG58942
anti-IBSP / Bone Sialoprotein antibody
anti-IBSP / Bone Sialoprotein antibody for IHC-Formalin-fixed paraffin-embedded sections and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes IBSP / Bone Sialoprotein |
|---|---|
| 反应物种 | Hu |
| 预测物种 | Dog |
| 应用 | IHC-P |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | IBSP / Bone Sialoprotein |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide around the N-terminal region of Human IBSP / Bone Sialoprotein. (within the following region: SATTLGYGEDATPGTGYTGLAAIQLPKKAGDITNKATKEKESDEEEEEEE) |
| 偶联标记 | Un-conjugated |
| 別名 | Integrin-binding sialoprotein; BSP II; BSP; SP-II; Bone sialoprotein 2; BSP-II; Bone sialoprotein II; Cell-binding sialoprotein; BNSP |
应用说明
| 预测反应性说明 | Predicted Homology Based On Immunogen Sequence: Dog: 79% | ||||
|---|---|---|---|---|---|
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A. |
| 缓冲液 | PBS, 0.09% (w/v) Sodium azide and 2% Sucrose. |
| 抗菌剂 | 0.09% (w/v) Sodium azide |
| 稳定剂 | 2% Sucrose |
| 浓度 | Batch dependent: 0.5 - 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | IBSP |
| 全名 | integrin-binding sialoprotein |
| 背景介绍 | The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor. [provided by RefSeq, Jul 2008] |
| 生物功能 | Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment. [UniProt] |
| 细胞定位 | Secreted. [UniProt] |
| 预测分子量 | 35 kDa |
| 翻译后修饰 | N-glycosylated; glycans consist of sialylated and core-fucosylated bi-, tri- and tetraantennary chains. O-glycosylated at eight sites; mucin-type glycans contain Gal, GlcNAc, GalNAc and terminal NeuAc. Sulfated on either Tyr-313 or Tyr-314. [UniProt] |
