ARG57915
anti-HtrA2 / Omi antibody
anti-HtrA2 / Omi antibody for IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes HtrA2 / Omi |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | IHC-P, IP, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | HtrA2 / Omi |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide derived from Human HtrA2 / Omi. |
| 偶联标记 | Un-conjugated |
| 別名 | Serine protease HTRA2, mitochondrial; Serine proteinase OMI; Omi stress-regulated endoprotease; OMI; EC 3.4.21.108; PARK13; High temperature requirement protein A2; PRSS25; Serine protease 25; HtrA2 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 阳性对照 | Jurkat | ||||||||
| 实际分子量 | ~ 39 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.4), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # O43464 Human Serine protease HTRA2, mitochondrial Swiss-port # Q9JIY5 Mouse Serine protease HTRA2, mitochondrial |
|---|---|
| 基因名称 | HTRA2 |
| 全名 | HtrA serine peptidase 2 |
| 背景介绍 | This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined. [provided by RefSeq, Jul 2008] |
| 生物功能 | Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive. [UniProt] |
| 细胞定位 | Mitochondrion membrane > Single-pass membrane protein. [UniProt] |
| 预测分子量 | 49 kDa |
| 翻译后修饰 | Autoproteolytically activated. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG57915 anti-HtrA2 / Omi antibody WB image
Western blot: Jurkat cell lysate stained with ARG57915 anti-HtrA2 / Omi antibody.
