ARG67264
anti-Histone H3 (K27M Mutant) antibody [SQab30380]
anti-Histone H3 (K27M Mutant) antibody [SQab30380] for IHC-Formalin-fixed paraffin-embedded sections and Human
概述
| 产品描述 | Rabbit Monoclonal antibody [SQab30380] recognizes Histone H3 (K27M Mutant). |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P |
| 特异性 | This antibody is specificity for mutated K27M. |
| 宿主 | Rabbit |
| 克隆 | Monoclonal |
| 克隆号 | SQab30380 |
| 同位型 | IgG |
| 靶点名称 | Histone H3 (K27M Mutant) |
| 抗原 | Synthetic peptide. |
| 偶联标记 | Un-conjugated |
| 別名 | H3C1; H3 Clustered Histone 1; HIST1H3A; H3/A; H3FA; Histone Cluster 1 H3 Family Member A; H3 Histone Family, Member A; Histone Cluster 1, H3a; Histone 1, H3a; Histone H3.1; Histone H3/A; H3FC HIST1H3C; Histone H3/B; Histone H3/C; Histone H3/D; Histone H3/F; Histone H3/H; Histone H3/I; Histone H3/J; Histone H3/K; Histone H3/L; HIST1H3B; HIST1H3D; HIST1H3E; HIST1H3F; HIST1H3G; HIST1H3H; HIST1H3I; HIST1H3J; H3C10; H3C11; H3C12; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3FL; H3FB; H3FD; H3FI; H3FH; H3FK; H3FF; H3FJ |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS, 0.01% Sodium azide, 40% Glycerol and 0.05% BSA. |
| 抗菌剂 | 0.01% Sodium azide |
| 稳定剂 | 40% Glycerol and 0.05% BSA |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | H3C1 |
| 全名 | H3 Clustered Histone 1 |
| 背景介绍 | Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015] |
| 生物功能 | HIST1H3B or HIST1H3C mutations affecting residue Lys-37 of histone H3.1 are involved in the pathogenesis of pediatric undifferentiated soft tissue sarcomas. The mechanism through which mutations lead to tumorigenesis involves altered histones methylation with gain of global H3K27 methylation, altered Polycomb repressive complex 1 (PRC1) activity, aberrant epigenetic regulation of gene expression and impaired differentiation of mesenchimal progenitor cells. [Uniprot] |
| 细胞定位 | Chromosome, Nucleosome core, Nucleus. [Uniprot] |
| 预测分子量 | 15 kDa |
| 翻译后修饰 | Acetylation. [Uniprot] |
检测图片 (1) Click the Picture to Zoom In
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ARG67264 anti-Histone H3 (K27M Mutant) antibody [SQab30380] IHC-P image
Immunohistochemistry: Human H3 K27M-altered diffuse midline gliomas stained with ARG67264 anti-Histone H3 (K27M Mutant) antibody [SQab30380] at 1:100 dilution.
