ARG43805
anti-HMGN3 antibody
anti-HMGN3 antibody for Western blot and Mouse
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes HMGN3 |
|---|---|
| 反应物种 | Ms |
| 预测物种 | Hu, Rat |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | HMGN3 |
| 抗原物种 | Human |
| 抗原 | Recombinant full length protein corresponding to HMGN3 |
| 偶联标记 | Un-conjugated |
| 別名 | HMGN3; High Mobility Group Nucleosomal Binding Domain 3; TRIP7; High Mobility Group Nucleosome-Binding Domain-Containing Protein 3; TR-Interacting Protein 7; Thyroid Hormone Receptor Interacting Protein 7; Thyroid Receptor-Interacting Protein 7; Thyroid Hormone Receptor Interactor 7; PNAS-24; PNAS-25; TRIP-7 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | Mouse adrenal gland | ||||
| 实际分子量 | 11 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen |
| 缓冲液 | pH 7.4 PBS, 0.05% NaN3, and 40% Glycerol |
| 浓度 | 0.7 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q9DCB1 Mouse High mobility group nucleosome-binding domain-containing protein 3 |
|---|---|
| 基因名称 | HMGN3 |
| 全名 | High Mobility Group Nucleosomal Binding Domain 3 |
| 背景介绍 | The protein encoded by this gene binds thyroid hormone receptor beta in the presence of thyroid hormone. The encoded protein, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. There is a related pseudogene on chromosome 1. [provided by RefSeq, Jan 2016] |
| 生物功能 | Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function (By similarity). ( HMGN3_HUMAN,Q15651 ) |
| 细胞定位 | Nucleus |
| 预测分子量 | 11 kDa |
| 翻译后修饰 | Phosphoprotein |
检测图片 (1) Click the Picture to Zoom In
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ARG43805 anti-HMGN3 antibody WB image
Western blot: 40 µg of mouse adrenal gland tissu stained with ARG43805 anti-HMGN3 antibody at dilution 1: 500.
