anti-HLA G antibody [SQab30313]

anti-HLA G antibody [SQab30313] for IHC-Formalin-fixed paraffin-embedded sections and Human


产品描述 Recombinant rabbit Monoclonal antibody [SQab30313] recognizes HLA G
反应物种 Hu
应用 IHC-P
宿主 Rabbit
克隆 Monoclonal
克隆号 SQab30313
同位型 IgG
靶点名称 HLA G
抗原物种 Human
抗原 Recombinant protein of Human HLA G.
偶联标记 Un-conjugated
Protein Full name HLA class I histocompatibility antigen, alpha chain G
別名 HLA-G, Major Histocompatibility Complex, Class I, G, HLA Class I Histocompatibility Antigen, Alpha Chain G, HLA-G Histocompatibility Antigen, Class I, G, MHC Class I Antigen G, B2 Microglobulin, HLA G Antigen, Mutant MHC Class Ib Antigen, Mutant MHC Class I Antigen, MHC Class Ib Antigen, HLA-6.0, MHC-G, HLAG


应用 推荐稀释比
IHC-P1:50 - 1:100
应用说明 The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照 Human placenta


形式 Liquid
纯化 Purification with Protein A.
缓冲液 PBS, 0.01% Sodium azide, 40% Glycerol and 0.05%BSA.
抗菌剂 0.01% Sodium azide
稳定剂 40% Glycerol and 0.05%BSA
存放说明 For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项 For laboratory research only, not for drug, diagnostic or other use.



GeneID: 3135 Human HLA-G

Swiss-port # P17693 Human HLA class I histocompatibility antigen, alpha chain G

基因名称 HLA-G
全名 Major Histocompatibility Complex, Class I, G
背景介绍 HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]
生物功能 Non-classical major histocompatibility class Ib molecule involved in immune regulatory processes at the maternal-fetal interface. In complex with B2M/beta-2 microglobulin binds a limited repertoire of nonamer self-peptides derived from intracellular proteins including histones and ribosomal proteins.Peptide-bound HLA-G-B2M complex acts as a ligand for inhibitory/activating KIR2DL4, LILRB1 and LILRB2 receptors on uterine immune cells to promote fetal development while maintaining maternal-fetal tolerance.Upon interaction with KIR2DL4 and LILRB1 receptors on decidual NK cells, it triggers NK cell senescence-associated secretory phenotype as a molecular switch to promote vascular remodeling and fetal growth in early pregnancy. [Uniprot]
细胞定位 Cell membrane, Cell projection, Endoplasmic reticulum, Endosome, Membrane
预测分子量 38 kDa
翻译后修饰 N-glycosylated.1 Publication. Soluble HLA class I histocompatibility antigen, alpha chain G Produced by proteolytic cleavage at the cell surface (shedding) by matrix metalloproteinase MMP2. [Uniprot]

检测图片 (1) Click the Picture to Zoom In

  • ARG67037 anti-HLA G antibody [SQab30313] IHC-P image

    Immunohistochemistry: Formalin-fixed and paraffin-embedded human placenta stained with ARG67037 anti-HLA G antibody [SQab30313].