ARG54222
anti-HLA B7 antibody [BB7.1] (PE)
anti-HLA B7 antibody [BB7.1] (PE) for Flow cytometry and Human,Primates
Immune System antibody
概述
| 产品描述 | PE-conjugated Mouse Monoclonal antibody [BB7.1] recognizes HLA B7 |
|---|---|
| 反应物种 | Hu, NHuPrm |
| 应用 | FACS |
| 特异性 | The clone BB7.1 recognizes the HLA-B7 antigen. Although highly specific, it can cross-react with HLA-B42 antigen. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | BB7.1 |
| 同位型 | IgG1 |
| 靶点名称 | HLA B7 |
| 抗原 | Papain solubilised HLA-A2, B7 |
| 偶联标记 | PE |
| 別名 | SPDA1; HLAB; AS; MHC class I antigen B*7; HLA class I histocompatibility antigen, B-7 alpha chain |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化说明 | The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary. |
| 缓冲液 | PBS, 15 mM Sodium azide and 0.2% (w/v) high-grade protease free BSA |
| 抗菌剂 | 15 mM Sodium azide |
| 稳定剂 | 0.2% (w/v) high-grade protease free BSA |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P01889 Human HLA class I histocompatibility antigen, B-7 alpha chain |
|---|---|
| 基因名称 | HLA-B |
| 全名 | major histocompatibility complex, class I, B |
| 背景介绍 | HLA-B7 allele of human HLA class I major histocompatibility (MHC) antigen indicates higher risk of breast cancer and cervical cancer. Expression of HLA-B7 together with HLA-B27 is associated with increased susceptibility to spondyloarthropaties. Flow cytometry detection of these two alleles is being used to screen for patients, who suffer from inflammatory disorders affecting the sacroiliac and intervertebral joints, such as ankylosing spondylosis (AS). The HLA-B7 antigen (11 alleles) is expressed in 22% of healthy Caucasian individuals. |
| 生物功能 | Involved in the presentation of foreign antigens to the immune system. [UniProt] |
| 研究领域 | Immune System antibody |
| 预测分子量 | 40 kDa |
| 翻译后修饰 | Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity). |
克隆号文献
Monoclonal antibodies for analysis of the HLA system.
