ARG65414
anti-HLA A2 antibody [BB7.2] (azide free)
anti-HLA A2 antibody [BB7.2] (azide free) for Flow cytometry,Immunoprecipitation and Human
Immune System antibody
概述
| 产品描述 | Azide free Mouse Monoclonal antibody [BB7.2] recognizes HLA A2 |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS, IP |
| 特异性 | The clone BB7.2 recognizes an epitope at the C-terminus of alpha-2 helix and a turn on one of the underlying beta strands within the human HLA-A2 histocompatibility antigen. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | BB7.2 |
| 同位型 | IgG2b |
| 靶点名称 | HLA A2 |
| 抗原 | HLA-A2 solubilised by papain. |
| 偶联标记 | Un-conjugated |
| 別名 | MHC class I antigen A*1; HLAA; HLA class I histocompatibility antigen, A-1 alpha chain |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A. |
| 纯化说明 | 0.2 µm filter sterilized. |
| 纯度 | > 95% (by SDS-PAGE) |
| 缓冲液 | PBS (pH 7.4) |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P30443 Human HLA class I histocompatibility antigen, A-1 alpha chain |
|---|---|
| 基因名称 | HLA-A |
| 全名 | major histocompatibility complex, class I, A |
| 背景介绍 | HLA-A2 (44 kDa) is the most frequent HLA-A allele in human ethnic populations. HLA-A, together with HLA-B and HLA-C, represent human HLA class I major histocompatibility (MHC) antigens. These intrinsic membrane glycoproteins are expressed on nucleated cells and noncovalently associate with an invariant beta2 microglobulin. They carry foreign determinants important for immune recognition by cytotoxic T cells, thus important for anti-viral and anti-tumour defence._x000D_ |
| 生物功能 | Involved in the presentation of foreign antigens to the immune system. [UniProt] |
| 研究领域 | Immune System antibody |
| 预测分子量 | 40 kDa |
| 翻译后修饰 | Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity). |
检测图片 (1) Click the Picture to Zoom In
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ARG65414 anti-HLA A2 antibody [BB7.2] (azide free) FACS image
Flow Cytometry: Human peripheral blood cells stained with ARG65414 anti-HLA A2 antibody [BB7.2] (azide free), followed by incubation with APC labelled Goat anti-Mouse secondary antibody.
克隆号文献
Recurrence of melanoma following T cell treatment: continued antigen expression in a tumor that evades T cell recruitment.
Synergistic inhibition of natural killer cells by the nonsignaling molecule CD94.
Down-modulation of CD8αβ is a fundamental activity of primate lentiviral Nef proteins.
FACS / Human
HLA-A2-matched peripheral blood mononuclear cells from type 1 diabetic patients, but not nondiabetic donors, transfer insulitis to NOD-scid/γc(null)/HLA-A2 transgenic mice concurrent with the expansion of islet-specific CD8+ T cells.
FACS /
