ARG56304
anti-HIF1AN antibody
anti-HIF1AN antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes HIF1AN |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, IHC-P, IP, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | HIF1AN |
| 抗原物种 | Human |
| 抗原 | Recombinant protein of Human HIF1AN |
| 偶联标记 | Un-conjugated |
| 別名 | Factor inhibiting HIF-1; FIH-1; Hypoxia-inducible factor asparagine hydroxylase; Hypoxia-inducible factor 1-alpha inhibitor; EC 1.14.11.n4; EC 1.14.11.30; FIH1 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||||
| 阳性对照 | MCF7 |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q8BLR9 Mouse Hypoxia-inducible factor 1-alpha inhibitor Swiss-port # Q9NWT6 Human Hypoxia-inducible factor 1-alpha inhibitor |
|---|---|
| 基因名称 | HIF1AN |
| 全名 | hypoxia inducible factor 1, alpha subunit inhibitor |
| 生物功能 | Hydroxylates HIF-1 alpha at 'Asp-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation. [UniProt] |
| 预测分子量 | 40 kDa |
检测图片 (2) Click the Picture to Zoom In
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ARG56304 anti-HIF1AN antibody ICC/IF image
Immunofluorescence: U2OS cells stained with ARG56304 anti-HIF1AN antibody.
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ARG56304 anti-HIF1AN antibody WB image
Western blot: MCF7 cell lysate stained with ARG56304 anti-HIF1AN antibody.
