ARG41508
anti-HIF-1 beta antibody
anti-HIF-1 beta antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes HIF-1 beta |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | HIF-1 beta |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide of Human HIF-1 beta. |
| 偶联标记 | Un-conjugated |
| 別名 | HIF1BETA; Hypoxia-inducible factor 1-beta; Aryl hydrocarbon receptor nuclear translocator; HIF-1-beta; Class E basic helix-loop-helix protein 2; Dioxin receptor, nuclear translocator; HIF1B; TANGO; HIF1-beta; bHLHe2; ARNT protein; HIF-1beta |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | Human fetal kidney | ||||||
| 实际分子量 | ~ 87 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P27540 Human Aryl hydrocarbon receptor nuclear translocator |
|---|---|
| 基因名称 | ARNT |
| 全名 | aryl hydrocarbon receptor nuclear translocator |
| 背景介绍 | This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013] |
| 生物功能 | Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia. [UniProt] |
| 细胞定位 | Nucleus. [UniProt] |
| 预测分子量 | 87 kDa |
检测图片 (2) Click the Picture to Zoom In
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ARG41508 anti-HIF-1 beta antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human colon tissue stained with ARG41508 anti-HIF-1 beta antibody.
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ARG41508 anti-HIF-1 beta antibody WB image
Western blot: Human fetal kidney lysate stained with ARG41508 anti-HIF-1 beta antibody.
