ARG43824
anti-HIF-1 alpha antibody
anti-HIF-1 alpha antibody for ELISA,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes HIF-1 alpha |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ELISA, ICC/IF, IHC-P, WB |
| 特异性 | Human,Mouse,Rat |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | HIF-1 alpha |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide of human HIF-1alpha. |
| 偶联标记 | Un-conjugated |
| Protein Full name | Hypoxia-inducible factor 1-alpha |
| 別名 | HIF1A; Hypoxia Inducible Factor 1 Subunit Alpha; BHLHe78; PASD8; MOP1; Class E Basic Helix-Loop-Helix Protein 78; PAS Domain-Containing Protein 8; Member Of PAS Protein 1; HIF-1alpha; HIF1; Hypoxia Inducible Factor 1, Alpha Subunit (Basic Helix-Loop-Helix Transcription Factor); Basic-Helix-Loop-Helix-PAS Protein MOP1; Hypoxia-Inducible Factor 1-Alpha; HIF-1-Alpha; Hypoxia Inducible Factor 1 Alpha Subunit; Hypoxia-Inducible Factor1alpha; Member Of PAS Superfamily 1; ARNT Interacting Protein; ARNT-Interacting Protein; HIF1-ALPHA; HIF1-Alpha; BHLHE78; HIF-1A |
应用说明
| 应用建议 |
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| 实际分子量 | 92-130 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity Purified |
| 缓冲液 | Tris-Glycine, 50% Glycerol, 0.02% Sodium azide and 0.5% BSA |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol and 0.5% BSA |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | HIF1A |
| 全名 | Hypoxia Inducible Factor 1 Subunit Alpha |
| 背景介绍 | This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011] |
| 生物功能 | Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. [UniProt] |
| 细胞定位 | Cytoplasm, Nucleus. [UniProt] |
| 预测分子量 | 93 kDa |
| 翻译后修饰 | Acetylation, Glycoprotein, Hydroxylation, Isopeptide bond, Phosphoprotein, S-nitrosylation, Ubl conjugation. [UniProt] |
检测图片 (3) Click the Picture to Zoom In
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ARG43824 anti-HIF-1 alpha antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Mouse Colon tissue stained with ARG43824 anti-HIF-1 alpha antibody at 1:50 dilution.
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ARG43824 anti-HIF-1 alpha antibody WB image
Western blot: LOVO stained with ARG43824 anti-HIF-1 alpha antibody at 1:500 dilution.
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ARG43824 anti-HIF-1 alpha antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Rat Lung tissue stained with ARG43824 anti-HIF-1 alpha antibody at 1:50 dilution.
