ARG44487
anti-HEPACAM2 antibody
anti-HEPACAM2 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes HEPACAM2 |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | HEPACAM2 |
| 抗原物种 | Human |
| 抗原 | Human HEPACAM2 recombinant protein |
| 偶联标记 | Un-conjugated |
| 別名 | HEPACAM2; HEPACAM Family Member 2; Mitotic Kinetics Regulator; FLJ38683; MIKI |
应用说明
| 应用建议 |
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| 应用说明 | The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified with Immunogen. |
| 缓冲液 | 0.9% NaCl, 0.2% Na2HPO4, 0.05% Sodium azide and 4% Trehalose. |
| 抗菌剂 | 0.05% Sodium azide |
| 稳定剂 | 4% Trehalose |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | HEPACAM2 |
| 全名 | HEPACAM Family Member 2 |
| 背景介绍 | This gene encodes a protein related to the immunoglobulin superfamily that plays a role in mitosis. Knockdown of this gene results in prometaphase arrest, abnormal nuclear morphology and apoptosis. Poly(ADP-ribosylation) of the encoded protein promotes its translocation to centrosomes, which may stimulate centrosome maturation. A chromosomal deletion including this gene may be associated with myeloid leukemia and myelodysplastic syndrome in human patients. |
| 生物功能 | Required during prometaphase for centrosome maturation. Following poly-ADP-ribosylation (PARsylation) by TNKS, translocates from the Golgi apparatus to mitotic centrosomes and plays a key role in the formation of robust microtubules for prompt movement of chromosomes: anchors AKAP9/CG-NAP, a scaffold protein of the gamma-tubulin ring complex and promotes centrosome maturation. |
| 细胞定位 | Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane |
| 预测分子量 | 51 kDa |
| 翻译后修饰 | ADP-ribosylation, Disulfide bond, Glycoprotein |
检测图片 (2) Click the Picture to Zoom In
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ARG44487 anti-HEPACAM2 antibody IHC-P image
Immunohistochemistry: Human liver cancer stained with ARG44487 anti-HEPACAM2 antibody at 2 μg/mL dilution.
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ARG44487 anti-HEPACAM2 antibody WB image
Western blot: K562, HEL, Caco-2 and SH-SY5Y stained with ARG44487 anti-HEPACAM2 antibody at 0.5 μg/mL dilution.
