ARG24121
anti-HCN4 antibody [N114/10]
anti-HCN4 antibody [N114/10] for Flow cytometry,ICC/IF,IHC-Frozen sections,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat,Rabbit
概述
| 产品描述 | Mouse Monoclonal antibody [N114/10] recognizes HCN4 |
|---|---|
| 反应物种 | Hu, Ms, Rat, Rb |
| 应用 | FACS, ICC/IF, IHC-Fr, IHC-P, WB |
| 特异性 | ~130kDa. No cross-reactivity against other HCNs. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | N114/10 |
| 同位型 | IgG1 |
| 靶点名称 | HCN4 |
| 抗原物种 | Rat |
| 抗原 | Fusion protein amino of rat HCN4 |
| 偶联标记 | Un-conjugated |
| 別名 | HCN4; Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4; Potassium/Sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 4; Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 4; Hyperpolarization Activated Cyclic Nucleotide-Gated Cation Channel 4; BRGDA8; EIG18; SSS2 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 缓冲液 | PBS (pH 7.4), 50% Glycerol and 0.09% Sodium azide |
| 抗菌剂 | 0.09% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | HCN4 |
| 全名 | Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 |
| 背景介绍 | This gene encodes a member of the hyperpolarization-activated cyclic nucleotide-gated potassium channels. The encoded protein shows slow kinetics of activation and inactivation, and is necessary for the cardiac pacemaking process. This channel may also mediate responses to sour stimuli. Mutations in this gene have been linked to sick sinus syndrome 2, also known as atrial fibrillation with bradyarrhythmia or familial sinus bradycardia. Two pseudogenes have been identified on chromosome 15. |
| 生物功能 | Hyperpolarization-activated ion channel with very slow activation and inactivation exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) that regulate the rhythm of heart beat. May contribute to the native pacemaker currents in neurons (Ih). May mediate responses to sour stimuli. |
| 细胞定位 | Cell membrane, Membrane |
| 翻译后修饰 | Glycoprotein, Phosphoprotein |
检测图片 (4) Click the Picture to Zoom In
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ARG24121 anti-HCN4 antibody [N114/10] IHC-P image
Immunohistochemistry: Human hippocampus stained with ARG24121 anti-HCN4 antibody [N114/10] at 1:1000 dilution.
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ARG24121 anti-HCN4 antibody [N114/10] IHC-Fr image
Immunohistochemistry: Mouse brain stained with ARG24121 anti-HCN4 antibody [N114/10] at 1:1000 dilution.
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ARG24121 anti-HCN4 antibody [N114/10] ICC/IF image
Immunofluorescence: SH-SY5Y stained with ARG24121 anti-HCN4 antibody [N114/10] at 1:100 dilution.
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ARG24121 anti-HCN4 antibody [N114/10] WB image
Western blot: T-HEK stained with ARG24121 anti-HCN4 antibody [N114/10] at 1:1000 dilution.
