ARG67036
anti-HBsAg antibody [SQab30330]
anti-HBsAg antibody [SQab30330] for IHC-Formalin-fixed paraffin-embedded sections and HBV
概述
| 产品描述 | Recombinant rabbit Monoclonal antibody [SQab30330] recognizes HBSAg |
|---|---|
| 反应物种 | HBV |
| 应用 | IHC-P |
| 宿主 | Rabbit |
| 克隆 | Monoclonal |
| 克隆号 | SQab30330 |
| 同位型 | IgG |
| 靶点名称 | HBSAg |
| 抗原物种 | Human |
| 抗原 | Recombinant protein of Human HBSAg. |
| 偶联标记 | Un-conjugated |
| Protein Full name | Large envelope protein |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | HBV infected liver |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A. |
| 缓冲液 | PBS, 0.01% Sodium azide, 40% Glycerol and 0.05%BSA. |
| 抗菌剂 | 0.01% Sodium azide |
| 稳定剂 | 40% Glycerol and 0.05%BSA |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 基因名称 | S |
|---|---|
| 全名 | Large envelope protein |
| 背景介绍 | Systematic vaccination of individuals at risk of exposure to the virus has been the main method of controlling the morbidity and mortality associated with hepatitis B. The first hepatitis B vaccine was manufactured by the purification and inactivation of HBsAg obtained from the plasma of chronic hepatitis B virus carriers. The vaccine is now produced by recombinant DNA techniques and expression of the S isoform in yeast cells. The pre-S region do not seem to induce strong enough antigenic response. |
| 生物功能 | The large envelope protein exists in two topological conformations, one which is termed 'external' or Le-HBsAg and the other 'internal' or Li-HBsAg. In its external conformation the protein attaches the virus to cell receptors and thereby initiating infection. This interaction determines the species specificity and liver tropism. This attachment induces virion internalization predominantly through caveolin-mediated endocytosis. The large envelope protein also assures fusion between virion membrane and endosomal membrane. In its internal conformation the protein plays a role in virion morphogenesis and mediates the contact with the nucleocapsid like a matrix protein. [UniProt] |
| 细胞定位 | Cytoplasm |
| 预测分子量 | 42 kDa |
| 翻译后修饰 | Isoform M is N-terminally acetylated by host at a ratio of 90%, and N-glycosylated by host at the pre-S2 region. |
检测图片 (1) Click the Picture to Zoom In
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ARG67036 anti-HBSAg antibody [SQab30330] IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded HBV infected liver stained with ARG67036 anti-HBSAg antibody [SQab30330].
