ARG55486
anti-HAX1 antibody
anti-HAX1 antibody for ICC/IF,Western blot and Human,Mouse,Rat
Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody; Gene Regulation antibody; Metabolism antibody
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes HAX1 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | HAX1 |
| 抗原物种 | Human |
| 抗原 | Recombinant protein of Human HAX1 |
| 偶联标记 | Un-conjugated |
| 別名 | HCLS1-associated protein X-1; HS1BP1; HAX-1; HS1-binding protein 1; HS1-associating protein X-1; HSP1BP-1; SCN3; HCLSBP1 |
应用说明
| 预测反应性说明 | Rat | ||||||
|---|---|---|---|---|---|---|---|
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | Mouse brain and SH-SY5Y |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | HAX1 |
| 全名 | HCLS1 associated protein X-1 |
| 背景介绍 | The protein encoded by this gene is known to associate with hematopoietic cell-specific Lyn substrate 1, a substrate of Src family tyrosine kinases. It also interacts with the product of the polycystic kidney disease 2 gene, mutations in which are associated with autosomal-dominant polycystic kidney disease, and with the F-actin-binding protein, cortactin. It was earlier thought that this gene product is mainly localized in the mitochondria, however, recent studies indicate it to be localized in the cell body. Mutations in this gene result in autosomal recessive severe congenital neutropenia, also known as Kostmann disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| 生物功能 | Promotes cell survival. Potentiates GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. May regulate intracellular calcium pools. [UniProt] |
| 研究领域 | Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody; Gene Regulation antibody; Metabolism antibody |
| 预测分子量 | 32 kDa |
| 翻译后修饰 | Proteolytically cleaved by caspase-3 during apoptosis. |
检测图片 (2) Click the Picture to Zoom In
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ARG55486 anti-HAX1 antibody ICC/IF image
Immunofluorescence: A549 cells stained with ARG55486 anti-HAX1 antibody.
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ARG55486 anti-HAX1 antibody WB image
Western blot: Mouse brain and SH-SY5Y cell lysates stained with ARG55486 anti-HAX1 antibody.
