概述

产品描述	Rabbit Polyclonal antibody recognizes HAND2
反应物种	Hu, Ms, Rat
应用	ICC/IF, WB
宿主	Rabbit
克隆	Polyclonal
同位型	IgG
靶点名称	HAND2
抗原物种	Human
抗原	Recombinant fusion protein corresponding to aa. 1-217 of Human HAND2 (NP_068808.1).
偶联标记	Un-conjugated
別名	Class A basic helix-loop-helix protein 26; Thing2; DHAND2; bHLHa26; Hed; Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2; dHand; Heart- and neural crest derivatives-expressed protein 2; dHAND

应用说明

应用建议	应用 推荐稀释比 ICC/IF 1:50 - 1:200 WB 1:500 - 1:2000
应用说明	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

属性

形式	Liquid
纯化	Affinity purified.
缓冲液	PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
抗菌剂	0.02% Sodium azide
稳定剂	50% Glycerol
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 15111 Mouse HAND2 GeneID: 64637 Rat HAND2 GeneID: 9464 Human HAND2 Swiss-port # P61295 Rat Heart- and neural crest derivatives-expressed protein 2 Swiss-port # P61296 Human Heart- and neural crest derivatives-expressed protein 2 Swiss-port # Q61039 Mouse Heart- and neural crest derivatives-expressed protein 2 More
基因名称	HAND2
全名	heart and neural crest derivatives expressed 2
背景介绍	The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, this transcription factor plays an important role in limb and branchial arch development. [provided by RefSeq, Jul 2008]
生物功能	Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3' (By similarity). [UniProt]
细胞定位	Nucleus. [UniProt]
预测分子量	24 kDa

检测图片 (1) Click the Picture to Zoom In